Department of Molecular Medicine
 

Adam Salmon Adam B.  SalmonPh.D.

Assistant Professor Tenure Track


Profile and Contact Information | Research | Laboratory


RESEARCH

 

Research Program

  1. Understanding the basic biology of aging by using targeted interventions to delay the aging process in mammals. A focus on the lab is understanding how the inhibition of the mTOR signaling pathway can be used to delay aging and improve health. We use both rodents and non-human primates as model systems to address these questions. Some key questions we address are 1) does mTOR inhibition have similar effects in both model systems, 2) can diet interact with the pro-longevity effects of mTOR inhibition, 3) could multi-drug treatments be used to promote longevity and reduce potential side-effects.

  2. Determining whether modulation of oxidative stress could regulate healthy lifespan; i.e., does reduction of oxidative stress slow the development of age-related disease? In particular, we are interested in studying the role of oxidative stress and protein oxidation in the development of metabolic dysfunction with age and obesity. The oxidative stress theory of aging has been one of the most prominent theories of why organisms age. Both aging and increased fat accumulation promote dysregulation of glucose metabolism, alterations in adipose tissue homeostasis, and declines in cellular function that are detrimental to overall health. Metabolic diseases like Type 2 diabetes currently affect a significant proportion of the world's population and their prevention could certainly lead to longer, healthier lives.

 

Selected Publications

  1. Lelegren M, Liu Y, Ross C, Tardif S, Salmon AB, Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate. Pathobiol Aging Age Relat Dis 6: 31793. (2016). PMCID: in process

  2. Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel M, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Nadon NL, Harrison DE. Longer lifespan in male mice treated with a non-feminizing steroid, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell (in press). 2016.

  3. Ross C, Salmon AB, Strong R, Fernandez E, Javors M, Richardson A, Tardif S. Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus). Aging (Albany, NY) 7(11):964-973. (2015). PMCID: PMC4694066.

  4. Styskal Hunnicut J, Liu Y, Richardson A, Salmon AB, MsrA overexpression targeted to the mitochondria, but not cytosol, preserves insulin sensitivity in diet-induced obese mice. PlosONE 10(10):e0139844. (2015). PMCID: PMC4598006

  5. Liu R, Pulliam DA, Liu Y, Salmon AB, Dynamic differences in oxidative stress and the regulation of metabolism with age in visceral versus subcutaneous adipose. Redox Biol 6:401-408. (2015). PMCID: PMC4572386

  6. Salmon AB, Lerner C, Ikeno Y, Motch Perrine S, McCarter R, Sell C. Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-1. Am J Physiol Endo Metabol 308(7):E545-E553. (2015). PMCID: PMC4385875.

  7. Zhang Y, Fischer KE, Soto V, Liu Y, Sosnowska D, Richardson A, Salmon AB, Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice. Arch Biochem Biophys 576:39-48. (2015). PMCID: PMC4456198.

  8. Liu Y, Diaz V, Fernandez E, Strong R, Ye L, Baur JA, Lamming DA, Richardson A, Salmon AB. Rapamycin-induced metabolic defects are reversible in both lean and obese mice. Aging (Albany, NY) 6(9):742-754. (2014). PMCID: PMC4221917.

  9. Tardif S, Ross C, Bergman P, Fernandez E, Javors M, Salmon A, Spross J, Strong R, Richardson A. Testing efficacy of administration of the anti-aging drug rapamycin in a non-human primate, the common marmoset. J Gerontol A Biol Sci Med Sci. 70(5):577-588. (2015). PMCID: PMC4400395

  10. Muscogiuri G, Salmon AB, Aguayo-Mazzucato C, Balas B, Guardado Mendoza R, Giacarri A, Reddick R, Reyna S, Weir G, DeFronzo R, Van Remmen H, Musi N. Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function. Diabetes 62(12):4201-4207. (2013).

  11. Liu Y, Qi W, Richardson A, Van Remmen H, Ikeno Y, Salmon AB. Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase. Biochem Biophys Res Comm 438(1):78-83. (2013).

  12. Styskal J, Nwagwu FA, Watkins YN, Liang H, Richardson A, Musi N, Salmon AB. Methionine sulfoxide reductase A affects insulin resistance by protecting insulin receptor function. Free Rad Biol Med 56:123-32. (2013).

  13. Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, and Baur JA: (2012) Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 335(6076): 1638-43.

  14. Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, and James DE: (2009) Insulin resistance is a cellular antioxidant defense mechanism. Proc Natl Acad Sci USA: 106(42): 17787-92.

  15. Salmon AB, Perez VI, Bokov A, Jernigan A, Kim G, Zhao H, Levine RL, and Richardson A: (2009) Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span. FASEB J. 23(10): 3601-8.



Complete list of published work.