Department of Molecular Medicine
 

[ default picture ] Chun-Lin  LinPh.D.

Assistant Professor/Research


Profile and Contact Information | Research


RESEARCH

 

Research Program

My research interests are cancer genomics, tumoral heterogeneity, and health disparity. I applied bioinformatic and biostatistic methods on analyzing genomic, transcriptomic, proteomic, and population health data. In one of my projects, I am interested in how tumor cells transit from in situ proliferation to distant colonization through blood circulation. To address this question, our lab conducted single-cell omics to investigate genomic, transcriptomic, and biophysical properties of circulating tumor cells (CTCs). Whereas primary tumor cells mainly deploy the Warburg effect to break down glucose for generating ATP and metabolic intermediates, we found CTCs exploit oxidative phosphorylation (OXPHOS) for energy fuels. The translational application is to develop strategies for therapeutic intervention on advanced prostate cancer. I have also expanded my work into disparities in cancer incidence/mortality in South Texas compared to nationwide areas. Knowing that the Hispanics contribute to a significant amount of population in South Texas, the disparities also reflect the impact of the race/ethnicity factor on cancer issues. One of my findings was that young Hispanic population had higher rates of uterus cancer compared to their counterpart in South Texas, and this disparity was not seen at the state and national levels. My future plan is to explore the dynamic interaction between aging factors and the incidence of uterus cancer among race/ethnicity subpopulations.

 

Selected Publications

  1. Polusani S, Huang Y-W, Huang G, Chen C-W, Wang C-M, Lin L-L, Osmulski P, Lucio N, Liu L, Hsu Y-T, Zhou Y, Lin C-L, Aguilera-Barrantes I, Valente P, Kost E, Chen C-L, Shim E Y, Lee S E, Ruan J, Gaczynska M, Yan P, Goodfellow P, Mutch D, Jin V, Nicholson B, Huang T, and Kirma N. Adipokines deregulate cellular communication via epigenetic repression of gap junction loci in obese endometrial cancer. Cancer Research 79(1) (2019)

  2. Horning AM, Wang Y, Lin C-K, Louie AD, Jadhav RR, Lin C-L, Kirma N, Liss MA, Kumar AP, Liu Z, Wang Q, Jin VX, Chen C-L, Huang TH-M. Single-cell RNA-seq reveals a hidden subpopulation of prostate cancer cells with enhanced cell cycle-related transcription and attenuated androgen response. Cancer Research 78 (4): 853-864 (2018)

  3. Huang G, Osmulski PA, Bouamar H, Mahalingam D, Lin C-L, Liss MA, Kumar AP, Chen C-L, Thompson IM, Sun L-Z, Gaczynska ME, Huang T H-M. TGF-β signal rewiring sustains epithelial-mesenchymal transition of circulating tumor cells in prostate cancer xenograft hosts. Oncotarget 7(47): 77124-77137 (2016). PMID: 27780930

  4. Shen-Gunther J, Wang C-M, Poage GM, Lin C-L, Perez L, Banks NA, Huang T H-M. Molecular Pap smear: HPV genotype and DNA methylation of ADCY8, CDH8, and ZNF582 as an integrated biomarker for high-grade cervical cytology. Clinical Epigenetics 8-96 (2016). PMID: 27651839

  5. Sunkel B, Wu D, Chen Z, Wang C-M, Liu X, Ye Z, Horning AM, Liu J, Mahalingam D, Lopez-Nicora H, Lin C-L, Goodfellow PJ, Clinton SK, Jin VX, Chen C-L, Huang T H-M, Wang Q. Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence. Nucleic Acids Research 44: 4105-4122 (2016). PMID:28419278

  6. Horning AM, Awe JA, Wang C-M, Liu J, Lai Z, Wang Y, Jadhav RR, Louie AD, Lin C-L, Kroczak T, Chen Y, Jin VX, Abboud-Werner SL, Leach RJ, Hernandez J, Thompson IM, Saranchuk J, Drachenberg D, Chen C-L, Mai S, Huang T H-M. DNA methylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemical recurrence. The Prostate 75: 1790-1801 (2015). PMID: 26332453

  7. Mishra S, Lin C-L, Huang T H-M, Bouamar H, Sun L-Z. MicroRNA-21 inhibits p57Kip2 expression in prostate cancer. Molecular Cancer 13:212 (2014). PMID: 25216674

  8. Ghosh S, Gu F, Wang C-M, Lin C-L, Liu J, Wang H, Ravdin P, Hu Y, Huang T H-M, Li R. Genome-Wide DNA Methylation Profiling Reveals Parity-Associated Hypermethylation of FOXA1. Breast Cancer Research and Treatment 147: 653-659 (2014). PMID: 25234841

  9. Mishra S, Deng JJ, Gowda PS, Rao MK, Lin C-L, Chen C-L, Huang T H-M, Sun L-Z. Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer. Oncogene 33: 4097-4106 (2014). PMID: 24037531