Department of Molecular Medicine
 

[ default picture ] Karthigayan  ShanmugasundaramPh.D.

Assistant Professor/Research


Profile and Contact Information | Research


RESEARCH

 

Selected Publications

  1. Shanmugasundaram K , Nayak BK, Friedrichs WE, Kaushik D, Rodriguez R, Block K. NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance. Nat Commun . 2017 Oct 19;8(1):997.

  2. Shanmugasundaram K , Block K. Renal Carcinogenesis, Tumor Heterogeneity, and ROS: Tactics Evolved. Antioxid Redox Signal . 2016 Jun 10.

  3. Nayak BK*, Shanmugasundaram K* , Friedrichs WE, Cavaglierii RC, Patel M, Barnes J, Block K. HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice. Diabetes . 2016 May;65(5):1387-97. (* equal contribution).

  4. Karthigayan Shanmugasundaram , Bijaya Nayak, Eun-Hee Shim, Carolina B. Livi, Karen Block, Sunil Sudarshan The Oncometabolite Fumarate Promotes Pseudohypoxia Through Noncannonical Activation of NF-κB Signaling. J Biol Chem . 2014 Jul 15.

  5. Hanyu Liang, Puntip Tantiwong, Apiradee Sriwijitkamol, Karthigayan Shanmugasundaram , Sumathy Mohan, John J Dubé, Ralph A DeFronzo, and Nicolas Musi. Effect of a Sustained Reduction in Plasma. Free Fatty Acid Concentration on Insulin Signaling and Inflammation in Skeletal Muscle from Human Subjects. J Physiol . 2013 Jun 1:2897-909.

  6. Shanmugasundaram K , Block K, Livi CB, Sudarshan S "PI3K regulation of the p27/SKP-2 axis through mTORC2". Oncogene. 2012 Jun 25.

  7. Fitzgerald JP, Nayak B, Shanmugasundaram K , Friedrichs W, Sudarshan S, Eid AA, Denapoli T, Parekh DJ, Gorin Y, Block K. Nox4 Mediates Renal Cell Carcinoma Cell Invasion through Hypoxia-Induced Interleukin 6- and 8- Production. PLoS One . 2012;7(1):e30712.

  8. Sudarshan S, Shanmugasundaram K , Naylor SL, Lin S, Livi CB, O'Neill CF, Parekh DJ, Yeh IT, Sun LZ, Block K. Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion. PLoS One . 2011;6(6):e21037

  9. Tantiwong, Puntip*, Shanmugasundaram K* , Sriwijitkamol A, Cersosimo E, DeFronzo RA, Mohan S, Musi N. NF-κB activity in muscle from obese and type 2 diabetic subjects under basal and exercise-stimulated conditions. Am J Physiol Endocrinol Metab . 2010 299(5):E794-801. (* equal contribution)

  10. Aravindan N, Shanmugasundaram K , Natarajan M. Hyperthermia induced NFkappaB mediated apoptosis in normal human monocytes. Mol Cell Biochem . 2009 Jul;327(1-2):29-37.

  11. Aravindan N, Aravindan S, Shanmugasundaram K , Shaw AD. Periods of systemic partial hypoxia induces apoptosis and inflammation in rat skeletal muscle. Mol Cell Biochem . 2007 Aug; 302(1-2):51-8.

  12. Karthigayan. S , Sri Balasubashini. M, Balasubramanian. T, Somasundaram. S.T. PGE from O.segina induces apoptosis in Ehrlich’s ascites carcinoma of mice. Toxicol Mech Meth . Volume 17, Issue 8, 2007, Pages 451 – 458

  13. Karthigayan. S , Sri Balasubashini. M, Sengottuvelan. M, Balasubramanian. T, Somasundaram. S.T, Anticancer Principles from salivary gland extract of Octopus ageina. IJCR . 2006. 2 (3); 242-252.

  14. Sri Balasubashini. M, Karthigayan. S , SomasundaramS.T, Balasubramanian. T, Viswanathan. P, Venugopal P Menon. In vivo and In vitro Characterization of the Biochemical and Pathological Changes Induced by Lionfish (Pterios Volitans) venom in Mice. Tox.Mech.Met . 2006 16 (1): 1-7.

  15. Sri Balasubashini. M, Karthigayan. S , SomasundaramS.T, Balasubramanian. T, Viswanathan. P, Raveendran. P, Venugopal P Menon. Fish venom (Pterios volitans) peptide reduces tumour burden and ameliorates oxidative stress in Ehrlich’s ascites carcinoma xenografted mice. Bioorg Med Chem Lett . 2006 16: 6219-6225.

  16. Sri Balasubashini. M, Karthigayan. S , SomasundaramS.T, Balasubramanian. T, Venugopal P Menon. FV peptide induces apoptosis in HEp 2 and HeLa cells: an insight into the mechanism of induction. J Carcinogenesis . 2006 5 (27):1-9.

  17. Karthikeyan, R., S. Karthigayan , M. Sri Balasubashini, S. Vijayalakshmi and T.Balasubramanian, 2007. Histopathological changes induced by mice after intramuscular injection of venom from spin-bellied sea snake, Lepemis curtus (Shaw, 1802). Journal of Pharmacology and Toxicology . 2(4): 307-318.

  18. Karthikeyan, R., S. Karthigayan , M. Sri Balasubashini, S. Vijayalakshmi, S.T. Somasundaram and T. Balasubramanian, Antitumor effect of snake venom (Hydrophis spiralis) on Erhlich Ascites Carcinoma bearing mice, International Journal of Cancer Research . 2007. 3 (4); 187-190.

  19. Karthikeyan, R., S. Karthigayan , M. Sri Balasubashini, S. Vijayalakshmi, S.T. Somasundaram and T. Balasubramanian. Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom. International Journal of Cancer Research . 2007. 3 (4); 167-173, 2007.

  20. Karthikeyan, R., S. Karthigayan , M. Sri Balasubashini, S.T. Somasundaram and T. Balasubramanian, Inhibition of Hep2 and HeLa cell proliferation in vitro and tumor growth in vivo by sea snake venom. Toxicon . 2008. 51; 157-161.