Department of Molecular Medicine

Dr. Zhao Lai Zhao  LaiPh.D.

Assistant Professor - Research

Profile and Contact Information | Research



Selected Publications

  1. Badouin H, Gouzy J, Grassa CJ, Murat F, Staton SE, Cottret L, Lelandais-Brière C, Owens GL, Carrère S, Mayjonade B, Legrand L, Gill N, Kane NC, Bowers JE, Hubner S, Bellec A, Bérard A, Bergès H, Blanchet N, Boniface MC, Brunel D, Catrice O, Chaidir N, Claudel C, Donnadieu C, Faraut T, Fievet G, Helmstetter N, King M, Knapp SJ, Lai Z, Le Paslier MC, Lippi Y, Lorenzon L, Mandel JR, Marage G, Marchand G, Marquand E, Bret-Mestries E, Morien E, Nambeesan S, Nguyen T, Pegot-Espagnet P, Pouilly N, Raftis F, Sallet E, Schiex T, Thomas J, Vandecasteele C, Varès D, Vear F, Vautrin S, Crespi M, Mangin B, Burke JM, Salse J, Muños S, Vincourt P, Rieseberg LH, Langlade NB. The sunflower genome provides insights into oil metabolism, flowering and Asterid evolution. Nature. 2017 Jun 1; 546(7656):148-152.

  2. Akiel MA, Guo C, Li X, Rajasekaran D, Mendoza RG, Robertson CL, Jariwala N, Subler MA, Windle JJ, Garcia D, Lai Z, Chen HH, Chen Y, Giashuddin S, Fisher PB, Wang X-Y, Sarkar D, IGFBP7 deletion promotes Hepatocellular Carcinoma. 2017, Hepatology, DOI: 10.1158/0008- 5472.CAN-16-2885

  3. Shen T, Sanchez HN, Garcia D, Lai Z, Casali P, Zan H. Genome-wide analysis of HDAC inhibitor-mediated modulation of microRNAs and mRNAs in B cells induced to undergo classswitch DNA recombination and plasma cell differentiation. 2017, J Vis Exp. In Press

  4. Shen-Gunther J, Wang Y, Lai Z, Poage GM, Perez L, Huang T. H.M. Deep sequencing of HPV E6/E7 genes reveals loss of genotypic diversity and gain of clonal dominance in high-grade intraepithelial lesions of the cervix. 2017, BMC Genomics, 18:231

  5. Barker MS, Li Z, Kidder T, Reardon C, Lai Z, Oliveira L, Scascitelli M, Rieseberg LH. Most Compositae (Asteraceae) are descendants of a paleohexaploid and all share a paleotetraploid ancestor with the Calyceraceae. 2016, Am. J. Bot. 103 (7): 1203-1211

  6. Jadhav RR, Wang Y, Hsu Y-T, Liu J, Garcia D, Lai Z, Huang TH, Jin V. Methyl-binding DNA capture sequencing for patient tissues, J Vis Exp. 2016 Oct 31;(116)

  7. Horning AM, Awe JA, Wang CM, Liu J, Lai Z, Wang VY, Jadhav RR, Louie AD, Lin CL, Kroczak T, Chen Y, Jin VX, Abboud-Werner SL, Leach R, Hernandez J, Thompson IM, Saranchuk J, Drachenberg D, Chen CL, Mai S, Huang TH. DNA methylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemical recurrence. Prostate. 2015 Nov; 75(15): 1790-801.

  8. Srivastava J, Siddiq A, Gredler R, Shen XN, Rajasekaran D, Robertson CL, Subler MA, Windle JJ, Dumur CI, Mukhopadhyay ND, Garcia D, Lai Z, Chen Y, Balaji, U, Fisher PB, Sarkar D. Astrocyte elevated gene-1 and c-Myc cooperate to promote hepatocarcinogenesis in mice. Hepatology. 2015 Mar; 61(3):915-29.

  9. Baute GJ, Kane NC, Grassa C, Lai Z, Rieseberg LH. Genome scans reveal candidate domestication and improvement genes in cultivated sunflower, as well as extensive postdomestication introgression with wild relatives. 2015, New Phytol. 206: 830–838

  10. Peng Y, Lai Z, Lane T, Rao MN, Okada M, Jasieniuk M, O'Geen H, Kim R, Sammons RD, Rieseberg LH, C. Neal Stewart Jr. De novo genome assembly of the economically-important weed Conyza canadensis from integrated data obtained from multiple platforms of nextgeneration sequence data. 2014, Plant Physiol. 166(3): 1241-54

  11. Dave B, Granados-Principal S, Zhu R, Benz S, Rabizadeh S, Soon-Shiong P, Yu KD, Shao Z, Li X, Gilcrease M, Lai Z, Chen Y, Huang TH, Shen H, Liu X, Ferrari M, Zhan M, Wong ST, Kumaraswami M, Mittal V, Chen X, Gross SS, Chang JC. Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling. Proc Natl Acad Sci U S A. 2014 Jun 17;111 (24):8838-43.

  12. Hodgins KA, Lai Z, Oliveira L, Still DW, Scascitelli M, Barker M, Kane NC, Dempewolf H, Kozik A, Kesseli R, Burke J, Michelmore R Rieseberg LH. Genomics of Compositae crops: Reference transcriptome assemblies, and evidence of hybridization with wild relatives. 2014, Mol Ecol Resour. 14(1): 166-177

  13. Renaut S, Grassa CJ, Yeaman S, Moyers BT, Lai Z, Kane NC, Bowers JE, Burke JM. Rieseberg LH. 2013. Number and size of genomic islands of differentiation do not vary with geography of speciation. Nat Commun. 4:1827

  14. Guggisberg A, Lai Z, Huang J, Rieseberg LH. Transcriptome divergence between introduced and native populations of Canada thistle, Cirsium arvense. 2013, New Phytol. 199(2): 595-608

  15. Dlugosch KM*, Lai Z*, Bonin A, Hierro J, Rieseberg LH. Allele Identification for Transcriptome- Based Population Genomics in the Invasive Plant Centaurea solstitialis. 2013, G3 (Bethesda), 3(2): 359-367 *Co-first author

  16. Hodgins KA, Lai Z, Nurkowski K, Huang J, Rieseberg LH. The molecular basis of invasiveness: differences in gene expression of native and introduced common ragweed (Ambrosia artemisiifolia) in stressful and benign environments. 2013, Molecular Ecol. 22(9): 2496-2510

  17. Peterson MP, Whittaker DJ, Ambreth S, Sureshchandra S, Buechlein A, Podicheti R, Choi JH, Lai Z, Mockatis K, Colbourne JK, Tang H, Ketterson ED. De novo transcriptome sequencing in a songbird, the dark-eyed junco (Junco hyemalis): Genomic tools for an ecological model system. 2012, BMC Genomics 13(1): 305.

  18. Scaglione D, Lanteri S, Acquadro A, Lai Z, Knapp SJ, Rieseberg LH, Portis E. Large-scale transcriptome characterization and mass discovery of SNPs in globe artichoke and its related taxa. Plant Biotechnol J. 2012 10(8): 956-969

  19. Lai Z, Kane NC, Kozik A, Hodgins K, Dlugosch KM, Barker MS, Matvienko M, Yu Q, Pearl SA, Bell GD, Turner KG, Zou Y, Grassa C, Guggisberg A, Adams KL, Anderson JV, Horvath DP, Kesseli R, Burke JM, Michelmore RW, Rieseberg LH. Genomics of Compositae weeds: EST libraries, microarrays and evidence of introgression. 2012, Am. J. Bot. 99(2): 209-218.

  20. Lai Z, Zou Y, Kane NC, Choi JH, Wang X, Rieseberg LH. Development of normalized cDNA libraries for 454 transcriptome sequencing. Population Genomics for the series 2012, Methods Mol. Bio. 888:119-33.

  21. Kane NC, Gill N, King MG, Bowers JE, Berges H, Gouzy J, Bachlava E, Langlade NB, Lai Z, Stewart M, Burke JM, Vincourt P, Knapp SJ, Rieseberg LH. Progress towards a reference genome for sunflower. 2011, Botany 89:429-437

  22. Dempewolf H, Kane NC, Ostevik K, Geleta M, Barker M, Lai Z, Stewart M, Bekele E, Engels J, Cronk Q, Rieseberg LH. Establishing genomic tools and resources for Guizotia abyssinica (L.f.) Cass. the development of a library of expressed sequence tags, microsatellite loci and the sequencing of its chloroplast genome. 2010, Molecular Ecology Notes 10:1048-1058

  23. Strasburg JL, Scotti-Saintagne C, Scotti I, Lai Z, Rieseberg LH. Genomic patterns of adaptive divergence between chromosomally differentiated sunflower species. 2009, Mol Biol Evol. 26:1341-1355

  24. Lai Z, Kane NC, Zou Y, Rieseberg LH. Natural variation of gene expression analysis between wild & weedy populations of Helianthus annuus. 2008, Genetics 179: 1881-1890

  25. Heesacker A, Kishore VK, Gao W, Tang S, Kolkman JM, Gingle A, Matvienko M, Kozik A, Michelmore RM, Lai Z, Rieseberg LH, Knapp SJ. SSRs Mined from the Sunflower EST Database: Abundance, Polymorphisms, and Cross-Taxa Utility. 2008, Theor. Appl. Genet. 117 (7): 1021-1029

  26. Church SA, Livingstone K, Lai Z, Kozik A, Michelmore R, Knapp SJ, Rieseberg LH. Using variable rate models to identify genes under selection in sequence pairs: their validity and limitations for EST sequences. 2007, J. Mol. Evol. 64(2): 171-180

  27. Timms L, Jimenez R, Chase M, Lavelle D, McHale L, Kozik A, Lai Z, Heesacker A, Knapp S, Rieseberg LH, Michelmore R, Kessli R. Analyses of synteny between Arabidopsis thaliana and species in the Asteraceae reveal a complex network of small syntenic segments and major chromosomal rearrangements. 2006, Genetics 173(4): 2227-2235

  28. Lai Z, Gross BL, Zou Y, Andrews J, Rieseberg LH. Microarray analysis reveals differential gene expression in hybrid sunflower species. 2006, Mol Ecol. 15(5), 1213-1227 (Cover)

  29. Lai Z, Livingston K, Zou Y, Church SA, Knapp SJ, Andrews J, Rieseberg LH. Identification and mapping of SNPs from ESTs in sunflower. 2005, Theor. Appl. Genet. 111(8): 1532-1544

  30. Lai Z, Nakazato T, Salmaso M, Burke JM, Tang S, Knapp SJ, Rieseberg LH. Extensive chromosomal repatterning and the evolution of sterility barriers in hybrid sunflower species. 2005, Genetics 171: 291-303

  31. Qiao H, Wang F, Zhao L, Zhou J, Lai Z, Zhang Y, Robbins T, Xue Y. The F-box protein AhSLF-S2 controls the pollen function of S-RNase based self-compatibility. 2004, Plant Cell 16: 2307-2322

  32. Burke JM, Lai Z, Salmaso M, Nakazato T, Tang S, Heesacker A, Knapp SJ, Rieseberg LH. Comparative mapping and rapid karyotypic evolution in the genus Helianthus. 2004, Genetics 167: 449-457

  33. Lexer C, Lai Z, Rieseberg LH. Candidate gene polymorphisms associated with salt tolerance in wild sunflower hybrids: implications for the origin of Helianthus paradoxus, a diploid hybrid species. 2004, New Phytol. 161(1): 225-233

  34. Rieseberg LH, Raymond O, Rosenthal DM, Lai Z, Livingstone K, Nakazato T, Durphy JL, Schwarzbach AE, Donovan LA, Lexer C. Major ecological transitions in wild sunflowers facilitated by hybridization. 2003, Science 301: 1211-1216

  35. Ma W, Zhou J, Lai Z, Zhang Y, Xue Y. The self-incompatibility (S) locus resides in a pericentromeric region in Antirrhinum. 2003, Acta Bot. Sin. 45: 1-5

  36. Liang L, Lai Z, Ma W, Zhang Y, Xue Y. AhSL28, a senescence-and phosphosphate starvationinduced S-like RNase gene in Antirrhinum. 2002, Biochimica et Biophysica Acta. 1579: 64-71,

  37. Lai Z, Ma W, Han B, Liang L, Zhang Y, Hong G, Xue Y. An F-box gene linked to the selfincompatibility (S) locus of Antirrhinum is expressed specifically in pollen and tapetum. 2002, Plant Mol. Biol. 50: 29-42

  38. Wang H, Huang J, Lai Z, Xue Y. F-box proteins in flowering plants. 2002, Chin. Sci. Bull. 47: 1497-1501

  39. Cui H, Lai Z, Xue Y. A rewarding fifteen years: From SLG to SCR/SP11. 2001, Acta Bot. Sin. 43: 1-5 (in Chinese)

  40. Lai Z, Cui H, Yang H, Xue Y. Molecular biology of self and non-self pollen recognition in flowering plants. 1999, Dev. Reprod. Bio. 8(2): 65-70